submitted by khyzer09 to The_Science_Cult [link] [comments] https://preview.redd.it/nvkic6yeay461.jpg?width=4000&format=pjpg&auto=webp&s=d1579f910e5e35228c986c956438a4c6dadd554b On September 22, 2020 the National Command and Operation Centre (NCOC). Announced the launch of phase 3 clinical trials in Pakistan for a potential vaccine being developed by China’s CanSino Biologics Inc. | Beijing Institute of Biotechnology for the novel coronavirus. Ad5-nCoV is a viral vector vaccine that has successfully passed the phase 1 and 2 clinical trials and now its success in phase 3 clinical trials is imminent. Ad5-nCoV is one of the most advanced candidates in vaccine development worldwide. It is a viral vector vaccine. A viral vector vaccine comprises of virus as a non-harmful virus as vector to which segment of viral gene against which vaccine is to be created is attached using recombinant DNA technology. This recombinant structure is when incorporated in a host it trigger an immune response. These vaccines are highly specific in delivering the genes to the target cells, highly efficient in the gene transduction, and efficiently induce the immune response. They offer a long term and high level of antigenic protein expression and therefore, have a great potential for prophylactic use as these vaccines trigger and prime the cytotoxic T cells (CTL) which ultimately leads to the elimination of the virus infected cells. Adenovirus vector vaccines of various sorts have gone into human trials for HIV, influenza, Ebola, tuberculosis, and malaria. In case of Ad5-nCoV, adenovirus type 5 is used as a viral vector that expresses the spike glycoprotein of SARS COV-2. For the development of SARS COV-2 vaccine the viral gene was cloned and constructed into adenovirus type 5 viral vector with E1 and E3 deletion using the Admax system. This vaccine was created as a liquid formulation that is allocated intramuscularly in the arms of the patient. During phase 1 and 2 when vaccine was injected following results were collected · Ad5-nCoV vaccine was tolerable in all group of adults and the only adverse effects collected were tolerable headache, mild fever and fatigue. · Ad5 vectored COVID-19 vaccine was immunogenic, inducing humoral and T-cell responses rapidly in most participants. · There was a four-fold increase in the RBD and S protein-specific neutralizing antibodies within 14 days of immunization and it peaked at day 28 of post-vaccination. · The preexisting anti Ad5 antibodies limited the response of immune response. BibliographyFeng-Cai Zhu*, Y.-H. L.-H.-H.-J.-X.-P.-S.-Y. (2020). Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine:. Lancet 2020, 10. |
Coronavirus Vaccines Pipeline Analysis submitted by mariarai1 to u/mariarai1 [link] [comments] The latest research report published by DPI Research entitled “Coronavirus Vaccines Pipeline Analysis” provides a complete view of the current proceedings within the market. The report delivers crucial data in the form of tables, charts, graphs and figures in a comprehensive study of the Coronavirus Vaccines Pipeline Analysis. Download Free Sample Report @ https://dpiresearch.com/request-a-free-sample-report/ “Coronavirus (COVID 19) Vaccine Pipeline Assessment 2020” provides a comprehensive analysis of the fast-evolving, high-growth global Coronavirus (COVID 19) vaccine market. The report offers the most up-to-date industry data on the actual market situation for the Coronavirus (COVID 19) vaccine. The report explores a detailed analysis of the introduction of the coronavirus, pathogen characteristics, signs and symptoms, transmission, and prevention. It also evaluates the vaccines developed against MERS-CoV and SARS-CoV. The report reviews a clear insight into the funding of the Coronavirus (COVID-19) vaccine research. The report also offers comprehensive information about the recruiting clinical trials statement by phase, trial status, study sponsor name, and study phase. The report investigates detailed insights about countries, territories, or areas with reported laboratory-confirmed Coronavirus (COVID-19) cases and deaths. Key trends in terms of collaboration and partnership deals are analyzed with details. The report concludes with the profiles of the key vaccine developers in the global coronavirus vaccine market. The key players are evaluated on the various parameters such as business overview, promising vaccine in clinical development, and recent development. Report Scope:
Key Vaccine Developers Covered in the Report
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Last week, the Hong-Kong listed CanSino Biological said that it’s taking its vaccine candidate for Ebola into phase 2 trials after preliminary safety data showed efficacy against Covid-19. CanSino will develop the vaccine along with the Beijing Institute of Biotechnology and the Academy of Military Medical Sciences. CanSino Biological/Beijing Institute of Biotechnology Academy of Military Medical Sciences’ Institute of Biotechnology Ad5-nCoV CanSino Biologics Coronavirus COVID-19 Vaccine 0 China’s CanSino Biologics recently disclosed that the company was advancing its SARS-CoV-2 vaccine to a Phase II clinical trial making this vaccine candidate lead contender in the global race for an approved vaccine product. A coronavirus vaccine tested for the first time in humans is safe and induces a rapid immune response, researchers at China's CanSino Biologics Inc reported on Friday in The Lancet medical journal. CanSino Biologics, Inc. Beijing Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China (Chine) Gamaleya Research Institute (Russie) Janssen Research & Development, Inc. Johnson & Johnson (Etats-Unis) Vaxart (Etats-Unis) Anhui Zhifei Longcom Biopharmaceutical/Institute of Microbiology, Chinese Academy of Sciences (Chine) University of Pittsburgh (Etats-Unis) 2. Phase de - CanSino Biologics, Inc. Beijing Institute of Biotechnology, CanSino Biologics/Beijing Institute of Biotechnology, et Inovio Pharmaceuticals font ainsi usage d'une lignée de cellules de rein de foetus dénommée HEK-293, issue d'un foetus avorté en 1972 aux Pays-Bas. Quant à la firme Janss... Lire la suite . Controverses autour de la vaccination contre le cancer du col de l’utérus This is a global phase III clinical trial to evaluate efficacy,safety, immuogenicity of Ad5-nCoV manufactured by Cansino and Beijing Institute of Biotechnology in health adults aged 18 years old and above. The study will be double-blind, placebo-controlled trial with participants randomly allocated 1:1 to placebo and experimental vaccine cohorts. TIANJIN, CHINA, January 2, 2020, CanSino Biologics Inc. (“CanSinoBIO” or the “Company”, 6185.HK) announced the appointment of Dr. Pierre Armand Morgon as Senior Vice President responsible for international business operation. The appointment indicated a further step forward in the Company’s commitment to global development and growth. march 17 (reuters) - cansino biologics inc: * co & institute of biotechnology, academy of military medical sciences jointly developing recombinant novel coronavirus vaccine Beijing approves CanSino Biologics's experimental Covid-19 vaccine for use in Chinese military By Ben Westcott, CNN 6/30/2020 Honor for fallen officer, impeachment trial, Groundhog Day: 5 things China-based CanSino Biologics has received regulatory approval to conduct Phase I clinical trial of recombinant novel coronavirus vaccine (adenovirus type 5 vector) candidate. The candidate is being developed in alliance with Beijing Institute of Biotechnology (BIB), based on the viral vector vaccine technology platform previously used to develop Ebola vaccine.
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